A safety study of oral tangeretin and xanthohumol administration to laboratory mice.

نویسندگان

  • Barbara W Vanhoecke
  • Femke Delporte
  • Eva Van Braeckel
  • Arne Heyerick
  • Herman T Depypere
  • Margareta Nuytinck
  • Denis De Keukeleire
  • Marc E Bracke
چکیده

BACKGROUND The detection of molecular targets for flavonoids in cell signalling has opened new perspectives for their application in medicine. Both tangeretin, a citrus methoxyflavone, and xanthohumol, the main prenylated chalcone present in hops (Humulus lupulus L.), act on the mitogen-activated protein kinase pathway and await further investigation for administration in vivo. MATERIALS AND METHODS A safety study was designed in laboratory mice orally administered concentrates of purified tangeretin (1 x 10(-4) M) or xanthohumol (5 x 10(-4) M) at libitum for 4 weeks. Blood samples were collected for the analysis of a variety of haematological and biochemical parameters. RESULTS A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatment with either tangeretin or xanthohumol. The parameters encompassed an integrity check of the following tissues and organs: bone marrow, liver, exocrine pancreas, kidneys, muscles, thyroid, ovaries and surrenal cortex. Furthermore, no differences were noted in the metabolism of proteins, lipids, carbohydrates and uric acid, as well as in ion concentrations. CONCLUSION All data indicate that oral administration of tangeretin or xanthohumol to laboratory mice does not affect major organ functions and opens the gate for further safety studies in humans.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Safety evaluation of oral Anethum graveolens L total hydroalcoholic extract in mice

Anethum graveolens L. (dill) is used widely in Asian food and folk medicine but its safety profile for further clinical studies has remained unclear. After administration of total hydroalcoholic extract to mice in acute, subacute and subchronic treatment periods, toxic responses were recoreded by clinical, biochemical, hematological and pathological examinations. Doses up to 2000 mg/kg in acute...

متن کامل

Single dose oral toxicity of methanol extract of baobab (Adansonia digitata Linn) fruit shell on biochemical and histopathological parameters in mice

Objectives: The natural origin of medicinal plants does not guaranteed their safety, as there are no sufficient studies on the safety, efficacy and toxicity to support their beneficial claims. Hence, this study aimed at investigating the oral acute toxicity of Adansonia digitata L. fruit shell extract on mice. Methods: Maceration method was employed for the extraction of Adansonia digitata fru...

متن کامل

Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.

BACKGROUND Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro. In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo. METHODS Female nude mice (n = 80) were inoculated subc...

متن کامل

Route of administration induced in vivo effects and toxicity responses of Zinc Oxide nanorods at molecular and genetic levels

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

متن کامل

The Comparison of intravenous and oral administration of anise plant on BALB/c mice with listeriosis

Background & Aim: Anise studies have demonstrated different properties such as anti-cancer, anti-fungal,   antibacterial, antioxidant, strengthen the liver, gastrointestinal tract,   wounds heal and strengthen the nerve cells. Outbreaks of listeriosis in the   general population are 7.0 per 100,000 populations. Pregnant women, infants,   the elderly and immunocompromised patien...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • In vivo

دوره 19 1  شماره 

صفحات  -

تاریخ انتشار 2005